| Sarlona Trinket | G | none | — | ERLW |
| Scarab of Protection | — | legendary | Yes | DMG |
| Scarab of Protection | — | legendary | Yes | XDMG |
| Scholar's Pack | G | none | — | PHB |
| Scholar's Pack | G|XPHB | none | — | XPHB |
| Scimitar of Speed | M | very rare | Yes | DMG |
| Scimitar of Speed | M|XPHB | very rare | Yes | XDMG |
| Scissors of Shadow Snipping | — | rare | by a fey or a spellcaster | WBtW |
| Scorpion Armor | HA | rare | Yes | ToA |
| Scorpion Ship | SPC|AAG | none | — | AAG |
| Scourge of Shadow | M | artifact | Yes | CoA |
| Scribe's Pen | — | common | by a creature with the Mark of Scribing | ERLW |
| Scroll of Protection (Aberrations) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Beasts) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Celestials) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Constructs) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Dragons) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Elementals) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Fey) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Fiends) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Giants) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Humanoids) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Monstrosities) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Oozes) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Plants) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection (Undead) | SC|XPHB | rare | — | XDMG |
| Scroll of Protection from Aberrations | SC|DMG | rare | — | DMG |
| Scroll of Protection from Beasts | SC|DMG | rare | — | DMG |
| Scroll of Protection from Celestials | SC|DMG | rare | — | DMG |
| Scroll of Protection from Elementals | SC|DMG | rare | — | DMG |
| Scroll of Protection from Fey | SC|DMG | rare | — | DMG |
| Scroll of Protection from Fiends | SC|DMG | rare | — | DMG |
| Scroll of Protection from Plants | SC|DMG | rare | — | DMG |
| Scroll of Protection from Undead | SC|DMG | rare | — | DMG |
| Scroll of Tarrasque Summoning | SC|DMG | legendary | — | IDRotF |
| Scroll of the Comet | SC|DMG | legendary | — | IDRotF |
| Scroll of Titan Summoning (Animal Lord) | SC|XPHB | legendary | — | XDMG |
| Scroll of Titan Summoning (Blob of Annihilation) | SC|XPHB | legendary | — | XDMG |
| Scroll of Titan Summoning (Colossus) | SC|XPHB | legendary | — | XDMG |
| Scroll of Titan Summoning (Elemental Cataclysm) | SC|XPHB | legendary | — | XDMG |
| Scroll of Titan Summoning (Empyrean) | SC|XPHB | legendary | — | XDMG |
| Scroll of Titan Summoning (Kraken) | SC|XPHB | legendary | — | XDMG |
| Scroll of Titan Summoning (Tarrasque) | SC|XPHB | legendary | — | XDMG |
| Sealing Wax | G | none | — | PHB |
| Secondhand Steal Trinket | G | none | — | BMT |
| Seeker Dart | R | uncommon | — | PotA |
| Sekolahian Worshiping Statuette | — | common | — | GoS |
| Selesnya Guild Signet | RG|DMG | uncommon | Yes | GGR |
| Selesnya Keyrune | — | rare | by a member of the Selesnya guild | GGR |
| Sending Stone | — | uncommon | — | AI |
